Basic benefit and medical policy
Avycaz (ceftazidime and avibactam)
Effective March 18, 2019, Avycaz (ceftazidime and avibactam) is covered for the following updated FDA-approved indications.
Avycaz (ceftazidime and avibactam) is indicated for the treatment of the following infections caused by designated susceptible Gram-negative microorganisms:
- Complicated intra-abdominal infections, known as cIAI, used in combination with metronidazole, in adult and pediatric patients 3 months and older
- Complicated urinary tract infections, known as cUTI, including pyelonephritis, in adult and pediatric patients 3 months and older
- Hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia, known as HABP and VABP, in patients 18 years and older
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Avycaz and other antibacterial drugs, Avycaz should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria.
Avycaz (ceftazidime and avibactam) is a combination of ceftazidime, a cephalosporin, and avibactam, a beta-lactamase inhibitor.
Dosing information:
Dosage of Avycaz in adult patients with creatinine clearance, known as CrCl, greater than 50 mL/min.
Infection: cIAI, cUTI including pyelonephritis, hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia
Dose: Avycaz 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams)
Frequency: Every eight hours
Infusion time: Two hours
Dosage of Avycaz in pediatric patients age 2 to less than 18 years old with estimated glomerular filtration rate, known as eGFR, greater than 50 mL/min/1.73 m2 and 3 months to less than 2 years without renal impairment
Infection: cIAI and cUTI including pyelonephritis
Age range: Ages 2 to less than 18 years old
Dose: Avycaz 62.5 mg/kg to a maximum of 2.5 grams (ceftazidime 50 mg/kg and avibactam 12.5 mg/kg to a maximum dose of ceftazidime 2 grams and avibactam 0.5 grams)
Infusion time/frequency: Two hours/every eight hours
Age range: 6 months to less than 2 years old
Dose: Avycaz 62.5 mg/kg (ceftazidime 50 mg/kg and avibactam 12.5 mg/kg)
Infusion time/frequency: Two hours/every eight hours
Age range: 3 months to less than 6 months
Dose: Avycaz 50 mg/kg (ceftazidime 40 mg/kg and avibactam 10 mg/kg)
Infusion time/frequency: Two hours/every eight hours
- For treatment of cIAI, metronidazole should be given concurrently.
- Recommended duration of treatment:
- cIAI: Five to 14 days
- cUTI including pyelonephritis: Seven to 14 days
- HABP/VABP: Seven to 14 days (adults only)
- Dosage in adult patients with renal impairment
Dosage of Avycaz in adult patients with renal impairment
Estimated creatinine clearance (mL/min):a 31 to 50
Dose:b Avycaz 1.25 grams (ceftazidime 1 gram and avibactam 0.25 grams)
Frequency: Every eight hours
Estimated creatinine clearance (mL/min):a 16 to 30
Dose:b Avycaz 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams)
Frequency: Every 12 hours
Estimated creatinine clearance (mL/min):a 6 to 15c
Dose:b Avycaz 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams)
Frequency: Every 24 hours
Estimated creatinine clearance (mL/min):a Less than or equal to 5c
Dose:b Avycaz 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams)
Frequency: Every 48 hours
aAs calculated using the Cockcroft-Gault formula.
bAll doses of Avycaz are administered over 2 hours
cBoth ceftazidime and avibactam are hemodialyzable; thus, administer Avycaz after hemodialysis on hemodialysis days.
Pharmacy doesn’t require prior authorization of this drug.
NDCs:
- 00456-2700-01
- 00456-2700-10
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