The Record header image

Forward to a friend  |  Subscribe  |  The Record Archive  |  Contacts  |  bcbsm.com  |  Print this article

May 2024

Most commercial members must try preferred product for Zynteglo

For dates of service on or after April 19, 2024, we’ve added a step therapy requirement for Zynteglo™ (betibeglogene autotemcel), HCPCS code J3590.

Preferred product for Zynteglo

Before April 19, 2024

On or after April 19, 2024

There isn’t a preferred product

Members must try and fail Casgevy™


This change affects Blue Cross Blue Shield of Michigan commercial members and Blue Care Network commercial members.

We’ve updated the Blue Cross and BCN utilization management medical drug list to reflect the preferred drug.

The drugs discussed above continue to require prior authorization through the NovoLogix® online tool.

Some Blue Cross commercial groups aren’t subject to these requirements

For Blue Cross commercial groups, this prior authorization requirement applies only to groups that participate in the standard commercial Medical Drug Prior Authorization Program for drugs administered under the medical benefit. To determine whether a group participates in the prior authorization program, see the Specialty Pharmacy Prior Authorization Master Opt-in/out Group list.

Note: Blue Cross and Blue Shield Federal Employee Program® members and UAW Retiree Medical Benefits Trust (non-Medicare) members don’t participate in the standard prior authorization program.

Additional information

For more information about medical benefit drugs, see the following pages on ereferrals.bcbsm.com:

Prior authorization isn’t a guarantee of payment. Health care practitioners need to verify eligibility and benefits for members.

NovoLogix is an independent company that provides an online prescription drug prior authorization tool for Blue Cross Blue Shield of Michigan and Blue Care Network.

No portion of this publication may be copied without the express written permission of Blue Cross Blue Shield of Michigan, except that BCBSM participating health care providers may make copies for their personal use. In no event may any portion of this publication be copied or reprinted and used for commercial purposes by any party other than BCBSM.

*CPT codes, descriptions and two-digit numeric modifiers only are copyright 2023 American Medical Association. All rights reserved.